RAPSODI PHOTOTHERAPY
Rapsodi Phototherapy FROM SPATIAL PROTON IRRADIATION TO PROTON FLASH IRRADIATION
RADIOBIOLOGICAL AND PHYSICAL EFFECTS OF VARIOUS PROTON RADIAATION DOSE RATE
From spatial proton irradiation to FLASH phototherapy
The project aims to create France’s first proton irradiation platform with 2 objectives:
1. Aerospace research by identifying strategies for protection against space radiation (very low rate)
2. To improve cancer treatment using FLASH phototherapyspan, wpml_nbsp (ultra-high rate)
This project is proposed by UNIVERSITE COTE D’AZUR
SUMMARY TECHNICAL FEATURES OF THE PROJECT
IMPACT OF LOW RATES OF SPACE PROTONS ON INERT AND LIVING MATTER
Space technologies are undergoing rapid expansion and France is one of the global leaders in the field. The space research programme includes domains which are fundamental for the development of new satellites, the military space sector, cyberspace and climate change monitoring. The physical conditions which these technologies and human beings are subject to are very harsh (temperature variations, radiation) and significantly affect the stability of instruments, the pathophysiology of individuals and the efficiency of space missions.
Beyond the space dimension, identifying patients who will be free from after-effects after radiotherapy and radiation-sensitive individuals, is a real public health problem. Phototherapy is currently an expanding radiotherapy technique which enables highly accurate treatment. It consists in irradiating tumours using particles (which are able to spare healthy tissue located behind the targeted tumour), while classic particles (electrons) also irradiate behind the target.
2021 > 2003
- THE RESEARCH CENTRE FOR HETEROEPITAXY AND ITS APPLICATIONS
- PHYSICS INSTITUTE OF NICE
- I3S LABORATORY
- INTERDISCIPLINARY INSTITUTE FOR ARTIFICIAL INTELLIGENCE
- INSTITUTE OF RESEARCH ON CANCER AND AGING
- THE NATIONAL CENTRE FOR SPACE STUDIES
- THE NATIONAL CENTRE FOR SCIENTIFIC RESEARCH
- THE ATOMIC ENERGY COMMISSION
- THE NATIONAL HEALTH AND MEDICAL RESEARCH INSTITUTE
- THE NATIONAL INSTITUTE OF NUCLEAR AND PARTICLE PHYSICS
- THE FRENCH RIVIERA SPACE OBSERVATION LABORATORY
- 2 INFINIS INSTITUTE OF PHYSICS
- HUBERT CURIEN LAB HC LABORATORY
- GSI HELMHOLTZ CENTRE FOR HEAVY ION RESEARCH
- INSTITUTE OF ELECTRONICS AND SYSTEMS IES
- FRENCH RIVIERA OBSERVATORY/ARTEMIS LISA TEAM
- TRANSPORTERS IN CANCER IMAGING AND RADIOTHERAPY TIRO UMR E4320
- LHNB LNE
- LPC CLERMONT FERRAND
- AIMA DEVELOPPEMENT
Creating a proton beam temporal shaping system
- ALTEN
- SPACE MEDEX
MEDEX has an R&D strategy to improve human space flight and health on earth through medical discoveries using space technology. It is part of the ESA business incubation programme of the European space agency for its transfer of technology to the non-spatial medical sector. SPACE MEDEX contributes to the research project on the impact of protons in the space and medical context by providing human resources (thesis vacancies and sandwich course students)
- AIRBUS DEFENCE AND SPACE SYSTEMS ENGINEERING / TESR
- CNES
- IXBLUE produces special optical fibres in silica, in particular erbium-doped fibre amplifiers (EDFA) for embedded gyroscopes in satellites, and special fibres for dosimetry under flash conditions.
- TEST ET RADIATIONS (TRAD)
- THALES ALENIA SPACE (TAS)
INNOVATION
INNOVATION The facilities at the CENTRE ANTOINE LACCASGNE are the only ones of their kind in the South of France and can be used for low-rate proton radiation on inert and living matter. The intended purpose is:
- To better understand the psychopathological phenomena of space travel
- To develop radiation protection methods which are useful in space and potentially on earth, especially in clinics
- To select the most radiation resistant materials to offer a solution to various establishments which often look for these platforms overseas
The FLASH upgrade would give the region an innovative therapeutic tool for some tumours, usable for patients, while other systems are currently unable to do this, both in France and elsewhere in the world. Facilitating the emergence of medical techniques such as FLASH THERAPY helps to reduce toxicities and increases recovery rates; so, there is a societal impact
- To improve patients’ quality of life
- To avoid relapses and treatment which place a strain on the healthcare budget
IMPACTS
The RAPSODI project will structure interdisciplinary research between the various laboratories in Sophia Antipolis and Université Côte d’Azur in partnership with industrial players, and will engender technology transfers in the various fields referred to.
IMPACTS/ SPACE ASPECT
IMPACTS / VOLET THERAPY ASPECT
IMPACTS / SOCIO-ECONOMIC ASPECT
